Unit

UNIT 8.1 The Heme Biosynthesis Pathway and Clinical Manifestations of Abnormal Function

  1. John D. Phillips,
  2. James P. Kushner

Published Online: 1 MAY 2001

DOI: 10.1002/0471140856.tx0801s00

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Phillips, J. D. and Kushner, J. P. 2001. The Heme Biosynthesis Pathway and Clinical Manifestations of Abnormal Function. Current Protocols in Toxicology. 00:8.1:8.1.1–8.1.10.

Author Information

  1. University of Utah Medical School, Salt Lake City, Utah

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: MAY 1999

Abstract

Biosynthesis of heme is important for both prokaryotes and eukaryotes. The enzymes for this multistep process are distributed between the cytosol and mitochondria in eukaryotes. In humans there are inherited and acquired disorders characterized by over synthesis of one or more enzymes or absence of an enzyme. This overview discusses each enzyme in the heme biosynthesis pathway.