UNIT 9.1 Overview of Heme Degradation Pathway

  1. Mahin D. Maines

Published Online: 1 MAY 2001

DOI: 10.1002/0471140856.tx0901s00

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Maines, M. D. 2001. Overview of Heme Degradation Pathway. Current Protocols in Toxicology. 00:9.1:9.1.1–9.1.5.

Author Information

  1. University of Rochester School of Medicine, Rochester, New York

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: MAY 1999


Heme oxygenase 1 and 2 activities are responsible for initiating most of the degradation of heme, although other enzyme pathways play a role as well. The degradation pathway also includes biliverdin reductase, the activity of which is coupled to oxidation of NADH and NADPH. This overview discusses the pathways and enzymes involved in heme degradation.