UNIT 11.3 Assessment of Spatial Memory

  1. Gary L. Wenk

Published Online: 1 MAY 2001

DOI: 10.1002/0471140856.tx1103s00

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Wenk, G. L. 2001. Assessment of Spatial Memory. Current Protocols in Toxicology. 00:11.3:11.3.1–11.3.18.

Author Information

  1. University of Arizona, Tucson, Arizona

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: MAY 1999


Behavioral tasks must be evaluated in terms of the cognitive functions they require. The tasks described in this unit are useful for detecting stimulation by drugs or a small electrical current, impairment of normal function by production of lesions or administration of a pharmacologic or toxicologic agent, recording activity during performance of a specific task, or behavioral phenotyping of transgenic or knockout mice. The radial arm maze test is used for basic working memory or working memory versus reference memory; the water maze task is used for spatial memory, spatial probe trials, or working memory; and the T-maze test is used for spatial memory, working versus reference memory, or spontaneous alternation.