UNIT 11.5 Testing for Organophosphate-Induced Delayed Polyneuropathy
Published Online: 1 MAY 2001
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Toxicology
How to Cite
Moretto, A. 2001. Testing for Organophosphate-Induced Delayed Polyneuropathy. Current Protocols in Toxicology. 00:11.5:11.5.1–11.5.14.
- Published Online: 1 MAY 2001
- Published Print: MAY 1999
Organophosphorous compounds may cause two distinct types of toxicity: acute cholinergic toxicity and organophosphate-induced delayed polyneuropathy (OPIDP). The ability of a compound to cause OPIDP is assessed as described by administering the compound to hens and screening the brain, spinal cord, and peripheral nerves for neuropathy target esterase activity to detect OPIDP and acetylcholinesterase activity to rule out the acute toxicity. This assay can also be used as part of a screen for protective agents.