Unit

UNIT 11.5 Testing for Organophosphate-Induced Delayed Polyneuropathy

  1. Angelo Moretto

Published Online: 1 MAY 2001

DOI: 10.1002/0471140856.tx1105s00

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Moretto, A. 2001. Testing for Organophosphate-Induced Delayed Polyneuropathy. Current Protocols in Toxicology. 00:11.5:11.5.1–11.5.14.

Author Information

  1. Università degli Studi di Padova, Padova, Italy

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: MAY 1999

Abstract

Organophosphorous compounds may cause two distinct types of toxicity: acute cholinergic toxicity and organophosphate-induced delayed polyneuropathy (OPIDP). The ability of a compound to cause OPIDP is assessed as described by administering the compound to hens and screening the brain, spinal cord, and peripheral nerves for neuropathy target esterase activity to detect OPIDP and acetylcholinesterase activity to rule out the acute toxicity. This assay can also be used as part of a screen for protective agents.