UNIT 11.10 Principles of Electrophysiology: An Overview

  1. Toshio Narahashi

Published Online: 1 NOV 2003

DOI: 10.1002/0471140856.tx1110s17

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Narahashi, T. 2003. Principles of Electrophysiology: An Overview. Current Protocols in Toxicology. 17:11.10:11.10.1–11.10.11.

Author Information

  1. Northwestern University Medical School, Chicago, Illinois

Publication History

  1. Published Online: 1 NOV 2003
  2. Published Print: AUG 2003


This overview gives brief accounts of the mechanism of nerve excitation, receptor/channel functions, cable properties of neurons, and voltage clamp and patch clamp principles. Among various aspects of electrophysiology, emphasis is placed on the mechanistic studies of receptors/channels. A few sample records of membrane currents are illustrated to aid reader's comprehension. Finally some useful reference books are given for more comprehensive information.


  • voltage clamp;
  • patch clamp;
  • cable properties;
  • receptors;
  • ion channels