UNIT 11.14 Methods to Produce Brain Hyperthermia

  1. Hari Shanker Sharma

Published Online: 1 MAR 2005

DOI: 10.1002/0471140856.tx1114s23

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Sharma, H. S. 2005. Methods to Produce Brain Hyperthermia. Current Protocols in Toxicology. 23:11.14:11.14.1–11.14.26.

Author Information

  1. Institute of Surgical Sciences University Hospital, Uppsala University, Uppsala, Sweden

Publication History

  1. Published Online: 1 MAR 2005
  2. Published Print: FEB 2005


With the increase in global warming, the problems of hyperthermia have recently attracted world-wide medical attention. Deaths due to heat-related illnesses that have occurred in many human populations in recent years are now recognized as a great social and medical problem. Interestingly, the detailed mechanisms of hyperthermia and probable therapeutic measures have still not been worked out. Thus, good experimental models to simulate hyperthermia under clinical conditions are needed to expand our knowledge in the field and to develop suitable therapeutic strategies in the future. This unit describes an animal model to induce hyperthermia that is comparable to the clinical situation. The model will be useful for studying the effects of heat-related illnesses on various organs and systems. Because hyperthermia is associated with brain dysfunction, methods to assess some crucial parameters of brain injury, such as breakdown of the blood-brain barrier and brain edema formation, are also described.


  • hyperthermia;
  • brain dysfunction;
  • cell injury;
  • blood-brain barrier;
  • brain edema;
  • rectal temperature;
  • anesthetics;
  • heat stress;
  • heat stroke