UNIT 12.7 Isolation of Cerebellar Granule Cells from Neonatal Rats

  1. Jan Oberdoerster

Published Online: 1 NOV 2001

DOI: 10.1002/0471140856.tx1207s09

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Oberdoerster, J. 2001. Isolation of Cerebellar Granule Cells from Neonatal Rats. Current Protocols in Toxicology. 9:12.7:12.7.1–12.7.10.

Author Information

  1. Aventis CropScience, Research Triangle Park, North Carolina

Publication History

  1. Published Online: 1 NOV 2001
  2. Published Print: AUG 2001


Cerebellar Granule Cells in Neurotoxicology (Jan Oberdoerster, Aventis Corporation, Research Triangle Park, North Carolina). Cultured neurons allow the researcher to investigate mechanisms of toxicity on a relatively uniform population of cells. Primary cultures of cerebellar granule cells are post-mitotic neurons that are readily isolated and may be used for experimental procedures including electrophysiology, neuronal maturation, and various biochemical and molecular analyses.