UNIT 13.5 In Vivo Assessment of Prenatal Developmental Toxicity in Rodents
Published Online: 1 AUG 2003
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Toxicology
How to Cite
Narotsky, M. G. and Kavlock, R. J. 2003. In Vivo Assessment of Prenatal Developmental Toxicity in Rodents. Current Protocols in Toxicology. 16:13.5:13.5.1–13.5.25.
- Published Online: 1 AUG 2003
- Published Print: MAY 2003
This unit presents two basic protocols for testing prenatal developmental toxicity in rodents. The standard protocol for assessing prenatal developmental toxicity, often referred to as a Segment II study, describes the methods used for performing cesarean sections and examining cesarean-delivered fetuses for external, skeletal, and visceral alterations. The protocol for the Chernoff/Kavlock assay, a developmental toxicity screen, describes methods for examining parturition, and postnatal growth and viability of prenatally exposed litters.
- prenatal developmental toxicity;
- Segment II;
- Chernoff/Kavlock assay