UNIT 14.1 Overview of Hepatotoxicity

  1. Sharon A. Meyer

Published Online: 1 AUG 2001

DOI: 10.1002/0471140856.tx1401s08

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Meyer, S. A. 2001. Overview of Hepatotoxicity. Current Protocols in Toxicology. 8:14.1:14.1.1–14.1.6.

Author Information

  1. University of Louisiana—Monroe, Monroe, Louisiana

Publication History

  1. Published Online: 1 AUG 2001
  2. Published Print: MAY 2001


This overview presents some of the salient features of liver biology and physiology that form the basis for a variety of experimental tools that are used for the study of chemical histopathology. Prevalence and risk of heptatoxicity are examined among a subset of chemicals from the EPA IRIS database. The goal is to provide an objective assessment of the magnitude of the problem of chemically-induced hepatotoxicity and contextual background against which the diversity of responses of the liver to toxicants and the analytical methods available for their study can be appreciated.