UNIT 14.3 Small Animal Models of Hemorrhagic Shock–Induced Liver Dysfunction

  1. Inge Bauer,
  2. Michael Bauer

Published Online: 1 MAY 2002

DOI: 10.1002/0471140856.tx1403s11

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Bauer, I. and Bauer, M. 2002. Small Animal Models of Hemorrhagic Shock–Induced Liver Dysfunction. Current Protocols in Toxicology. 11:14.3:14.3.1–14.3.8.

Author Information

  1. University of the Saarland, Homburg, Germany

Publication History

  1. Published Online: 1 MAY 2002
  2. Published Print: FEB 2002


Blood loss and ensuing circulatory failure continues to be the leading cause of death between the ages of 1 and 45 in most western countries. Hepatocellular dysfunction is a key feature of the pathophysiological sequelae of trauma/hemorrhage in patients surviving the first hours and hemorrhagic hypotension has been widely used as a model for indirect liver injury in the critically ill. This unit describes a low-flow ischemia model of the liver due to hemorrhagic hypotension that can be used to produce a reproducible and graded injury to the pericentral region of the acinus, which is critical for metabolism of xenobiotics. This protocol allows for measurement of cardiac output and regional flow.