UNIT 18.4 Use of Bronchoalveolar Lavage to Detect Lung Injury
Published Online: 1 SEP 2004
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Toxicology
How to Cite
Henderson, R. F. and Muggenburg, B. A. 2004. Use of Bronchoalveolar Lavage to Detect Lung Injury. Current Protocols in Toxicology. 21:18.4:18.4.1–18.4.10.
- Published Online: 1 SEP 2004
- Published Print: AUG 2004
This unit describes how bronchoalveolar lavage can be used in laboratory animals to sample the epithelial lining fluid of the lung for information on the degree of pulmonary inflammation induced by exposure to an airborne toxicant. The technique allows quantitative assessment of inflammatory responses and is valuable for providing dose-response information in exposed animals. Lavage fluid samples may also be used for proteomic analyses, and the protein expression profiles may be used to address specific mechanistic questions.
- inhalation toxicity;
- epithelial lining fluid;
- bronchoalveolar lavage;
- pulmonary toxicity