Unit

UNIT 18.4 Use of Bronchoalveolar Lavage to Detect Lung Injury

  1. Rogene F. Henderson,
  2. Bruce A. Muggenburg

Published Online: 1 SEP 2004

DOI: 10.1002/0471140856.tx1804s21

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Henderson, R. F. and Muggenburg, B. A. 2004. Use of Bronchoalveolar Lavage to Detect Lung Injury. Current Protocols in Toxicology. 21:18.4:18.4.1–18.4.10.

Author Information

  1. Lovelace Respiratory Research Institute, Albuquerque, New Mexico

Publication History

  1. Published Online: 1 SEP 2004
  2. Published Print: AUG 2004

Abstract

This unit describes how bronchoalveolar lavage can be used in laboratory animals to sample the epithelial lining fluid of the lung for information on the degree of pulmonary inflammation induced by exposure to an airborne toxicant. The technique allows quantitative assessment of inflammatory responses and is valuable for providing dose-response information in exposed animals. Lavage fluid samples may also be used for proteomic analyses, and the protein expression profiles may be used to address specific mechanistic questions.

Keywords:

  • lung;
  • inhalation toxicity;
  • epithelial lining fluid;
  • bronchoalveolar lavage;
  • pulmonary toxicity