UNIT 21.7 Measurement of Small Intestinal Damage
Published Online: 1 AUG 2010
Copyright © 2010 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Toxicology
How to Cite
Takeuchi, K. and Satoh, H. 2010. Measurement of Small Intestinal Damage. Current Protocols in Toxicology. 45:21.7:21.7.1–21.7.31.
- Published Online: 1 AUG 2010
- Published Print: AUG 2010
Many animal models have been devised for investigating the pathogenesis of intestinal lesions and for screening drugs for the treatment of intestinal ulcers in humans. Recently, particular attention has been focused on NSAID-induced intestinal lesions as a result of the development of the capsule endoscope and double-balloon endoscope. Ischemic enteritis, one of the most dramatic abdominal emergencies, is known to cause severe damage to the small intestine by a significant decrease of arterial blood flow in the small intestine. In this unit, two animal models for small intestinal damage induced by NSAIDs or intestinal ischemia are described. Also included are methods for lesion induction and evaluation of the damage as well as the measurement of pathogenic functional and biochemical changes. Curr. Protoc. Toxicol. 45:21.7.1-21.7.31. © 2010 by John Wiley & Sons, Inc.
- small intestinal damage;
- functional change;
- biochemical alteration