Unit

UNIT 21.7 Measurement of Small Intestinal Damage

  1. Koji Takeuchi,
  2. Hiroshi Satoh

Published Online: 1 AUG 2010

DOI: 10.1002/0471140856.tx2107s45

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Takeuchi, K. and Satoh, H. 2010. Measurement of Small Intestinal Damage. Current Protocols in Toxicology. 45:21.7:21.7.1–21.7.31.

Author Information

  1. Kyoto Pharmaceutical University, Kyoto, Japan

Publication History

  1. Published Online: 1 AUG 2010
  2. Published Print: AUG 2010

Abstract

Many animal models have been devised for investigating the pathogenesis of intestinal lesions and for screening drugs for the treatment of intestinal ulcers in humans. Recently, particular attention has been focused on NSAID-induced intestinal lesions as a result of the development of the capsule endoscope and double-balloon endoscope. Ischemic enteritis, one of the most dramatic abdominal emergencies, is known to cause severe damage to the small intestine by a significant decrease of arterial blood flow in the small intestine. In this unit, two animal models for small intestinal damage induced by NSAIDs or intestinal ischemia are described. Also included are methods for lesion induction and evaluation of the damage as well as the measurement of pathogenic functional and biochemical changes. Curr. Protoc. Toxicol. 45:21.7.1-21.7.31. © 2010 by John Wiley & Sons, Inc.

Keywords:

  • small intestinal damage;
  • NSAID;
  • ischemia;
  • functional change;
  • biochemical alteration