Unit

UNIT 22.1 Using Chemotherapeutic Drugs to Trigger Hematopoietic Stem Cell Activation and Determine Hematological Toxicity

  1. Nathan Boles

Published Online: 1 FEB 2011

DOI: 10.1002/0471140856.tx2201s47

Current Protocols in Toxicology

Current Protocols in Toxicology

How to Cite

Boles, N. 2011. Using Chemotherapeutic Drugs to Trigger Hematopoietic Stem Cell Activation and Determine Hematological Toxicity. Current Protocols in Toxicology. 47:22.1:22.1.1–22.1.6.

Author Information

  1. Neural Stem Cell Institute, Rensselaer, New York

Publication History

  1. Published Online: 1 FEB 2011
  2. Published Print: FEB 2011

Abstract

Hematopoietic stem cells (HSCs) replenish blood cells throughout the lifetime of an animal. Maintaining the HSC pool is of paramount importance to the survival of the organism. Thus, when treating a patient or an animal with chemotherapeutic agents, all care must be taken to ensure that the HSC pool is minimally damaged while simultaneously eradicating the target population. Discussed here is a method to assess the potency of chemotherapeutic drugs on the hematopoietic system, their ability to activate the HSC compartment, and the damage done to the HSC pool. Curr. Protoc. Toxicol. 47:22.1.1-22.1.6. © 2011 by John Wiley & Sons, Inc.

Keywords:

  • hematopoietic stem cells;
  • activation;
  • chemotherapy;
  • FACS