UNIT 2.14 Protein Structural Domains: Definition and Prediction

  1. Iakes Ezkurdia,
  2. Michael L. Tress

Published Online: 1 NOV 2011

DOI: 10.1002/0471140864.ps0214s66

Current Protocols in Protein Science

Current Protocols in Protein Science

How to Cite

Ezkurdia, I. and Tress, M. L. 2011. Protein Structural Domains: Definition and Prediction. Current Protocols in Protein Science. 66:2.14:2.14.1–2.14.16.

Author Information

  1. Spanish National Cancer Research Centre (CNIO)—Structural Biology and Biocomputing Programme, Madrid, Spain

Publication History

  1. Published Online: 1 NOV 2011
  2. Published Print: NOV 2011


Recognition and prediction of structural domains in proteins is an important part of structure and function prediction. This unit lists the range of tools available for domain prediction, and describes sequence and structural analysis tools that complement domain prediction methods. Also detailed are the basic domain prediction steps, along with suggested strategies for different protein sequences and potential pitfalls in domain boundary prediction. The difficult problem of domain orientation prediction is also discussed. All the resources necessary for domain boundary prediction are accessible via publicly available Web servers and databases and do not require computational expertise. Curr. Protoc. Protein Sci. 66:2.14.1-2.14.16. © 2011 by John Wiley & Sons, Inc.


  • structural domains;
  • domain parsing;
  • homology modeling;
  • ab initio predictions;
  • functional domains