UNIT 12.8 Detection and Analysis of Proteins Modified by O-Linked N-Acetylglucosamine
Published Online: 1 NOV 2011
Copyright © 2011 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Protein Science
How to Cite
Zachara, N. E., Vosseller, K. and Hart, G. W. 2011. Detection and Analysis of Proteins Modified by O-Linked N-Acetylglucosamine. Current Protocols in Protein Science. 66:12.8:12.8.1–12.8.33.
- Published Online: 1 NOV 2011
- Published Print: NOV 2011
O-GlcNAc is a common post-translational modification of nuclear, mitochondrial, and cytoplasmic proteins that is implicated in the etiology of type II diabetes and Alzheimer's disease, as well as cardioprotection. This unit covers simple and comprehensive techniques for identifying proteins modified by O-GlcNAc, studying the enzymes that add and remove O-GlcNAc, and mapping O-GlcNAc modification sites. Curr. Protoc. Protein Sci. 66:12.8.1-12.8.33. © 2011 by John Wiley & Sons, Inc.
- signal transduction;