Unit

UNIT 18.1 Introduction to Peptide Synthesis

  1. Gregg B. Fields

Published Online: 1 FEB 2002

DOI: 10.1002/0471140864.ps1801s26

Lab Protocol Title

Current Protocols in Protein Science

Current Protocols in Protein Science

Additional Information

How to Cite

Fields, G. B. 2002. Introduction to Peptide Synthesis. Current Protocols in Protein Science. 26:18.1:18.1.1–18.1.9.

Author Information

  1. Florida Atlantic University, Boca Raton, Florida

Publication History

  1. Published Online: 1 FEB 2002
  2. Published Print: DEC 2001

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Abstract

A number of synthetic peptides are significant commercial or pharmaceutical products, ranging from the dipeptide sugar-substitute aspartame to clinically used hormones, such as oxytocin, adrenocorticotropic hormone, and calcitonin. This unit provides an overview of the field of synthetic peptides and proteins, including their purification. It discusses selecting the solid support and common coupling reagents. Additional information is provided regarding common side reactions and synthesizing modified residues.

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