UNIT 18.1 Introduction to Peptide Synthesis

  1. Maciej Stawikowski,
  2. Gregg B. Fields

Published Online: 1 AUG 2012

DOI: 10.1002/0471140864.ps1801s69

Current Protocols in Protein Science

Current Protocols in Protein Science

How to Cite

Stawikowski, M. and Fields, G. B. 2012. Introduction to Peptide Synthesis. Current Protocols in Protein Science. 69:18.1:18.1.1–18.1.13.

Author Information

  1. Torrey Pines Institute for Molecular Studies, Port St. Lucie, Florida

Publication History

  1. Published Online: 1 AUG 2012
  2. Published Print: AUG 2012


A number of synthetic peptides are significant commercial or pharmaceutical products, ranging from the dipeptide sugar substitute aspartame to clinically used hormones such as oxytocin, adrenocorticotropic hormone, and calcitonin. This unit provides an overview of the field of synthetic peptides and proteins. It discusses selecting the solid support and common coupling reagents. Additional information is provided regarding common side reactions and synthesizing modified residues. Curr. Protoc. Protein Sci. 69:18.1.1-18.1.13. © 2012 by John Wiley & Sons, Inc.


  • peptide;
  • protein;
  • solid-phase peptide synthesis;
  • coupling reagent;
  • chemoselective ligation;
  • Fmoc–amino acid