Unit

UNIT 18.7 Guide for Resin and Linker Selection in Solid-Phase Peptide Synthesis

  1. Jason A. Moss

Published Online: 1 JUN 2005

DOI: 10.1002/0471140864.ps1807s40

Current Protocols in Protein Science

Current Protocols in Protein Science

How to Cite

Moss, J. A. 2005. Guide for Resin and Linker Selection in Solid-Phase Peptide Synthesis. Current Protocols in Protein Science. 40:18.7:18.7.1–18.7.19.

Author Information

  1. The Scripps Research Institute, La Jolla, California

Publication History

  1. Published Online: 1 JUN 2005
  2. Published Print: MAY 2005

Abstract

For both novice and experienced practitioners of solid-phase peptide synthesis (SPPS), the vast selection of commercially available linkers and resins has become something of a babel. The purpose of this unit is to clarify the situation, which is best understood by distillation to first principles, through an appreciation of chemical trends and consequences, as well as practical considerations. The most commonly used linkers and resins are presented and described in detail, along with a description of their development and common applications. Key protocols are provided so that the user may prepare appropriate linker-functionalized resins for the majority of peptide synthesis applications.

Keywords:

  • SPPS;
  • solid-phase;
  • resin;
  • linker;
  • peptide;
  • synthesis