UNIT 21.3 Overview of Pepsin-like Aspartic Peptidases

  1. Ben M. Dunn

Published Online: 1 NOV 2001

DOI: 10.1002/0471140864.ps2103s25

Current Protocols in Protein Science

Current Protocols in Protein Science

How to Cite

Dunn, B. M. 2001. Overview of Pepsin-like Aspartic Peptidases. Current Protocols in Protein Science. 25:21.3:21.3.1–21.3.6.

Author Information

  1. University of Florida College of Medicine, Gainesville, Florida

Publication History

  1. Published Online: 1 NOV 2001
  2. Published Print: SEP 2001


The aspartic peptidase family of enzymes has been implicated in a variety of disease states, from stomach ulcers, to breast cancer, and even Alzheimer's Disease. This unit describes the major characteristics of the aspartic peptidases, including mechanism of action, subcellular and tissue localization, and biological substrate specificity.