UNIT 21.4 Metalloproteases

  1. Hideaki Nagase

Published Online: 1 AUG 2001

DOI: 10.1002/0471140864.ps2104s24

Current Protocols in Protein Science

Current Protocols in Protein Science

How to Cite

Nagase, H. 2001. Metalloproteases. Current Protocols in Protein Science. 24:21.4:21.4.1–21.4.13.

Author Information

  1. Imperial College School of Medicine, London, United Kingdom

Publication History

  1. Published Online: 1 AUG 2001
  2. Published Print: JUN 2001


Metalloproteases (metallopeptidases) are composed of a diverse group of endopeptidases and exopeptidases. Because metalloproteases play key roles in many normal biological processes, their aberrant activities have been implicated in diseases such as arthritis, cancer, cardiovascular diseases, nephritis, disorders in the central nervous system, fibrosis, and infection, as well as others. This unit provides an overview of metalloproteases, including their classification, catalytic mechanisms, structures, substrate specificities, and common inhibitors.