UNIT 25.3 The Publication and Database Deposition of Molecular Interaction Data

  1. Sandra Orchard,
  2. Bruno Aranda,
  3. Henning Hermjakob

Published Online: 1 APR 2010

DOI: 10.1002/0471140864.ps2503s60

Current Protocols in Protein Science

Current Protocols in Protein Science

How to Cite

Orchard, S., Aranda, B. and Hermjakob, H. 2010. The Publication and Database Deposition of Molecular Interaction Data. Current Protocols in Protein Science. 60:25.3:25.3.1–25.3.13.

Author Information

  1. European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom

Publication History

  1. Published Online: 1 APR 2010
  2. Published Print: APR 2010


Depositing data to a public domain interaction database not only improves the quality and quantity of interactions available to the user community, but also increases the visibility of the data, with members of the International Molecular Exchange (IMEx) databases making the information available in all participating resources. Datasets submitted prior to publication will be issued an accession number that may be included in a publication and which increases user accessibility to the data. No dataset is too small for submission, and the database curators will provide assistance in ensuring the information is correctly represented. This unit provides several alternative protocols to assist the author in preparing and submitting data as an integral part of the manuscript-preparation process. Which method the author selects is largely dictated by the amount of data to be deposited. In addition, two support protocols describe assignment of unambiguous accession numbers and use of controlled vocabulary terms. Curr. Protoc. Protein Sci. 60:25.3.1-25.3.13. © 2010 by John Wiley & Sons, Inc.


  • molecular interaction;
  • data deposition;
  • IMEx;
  • data standardization