UNIT 29.1 Introduction to Membrane Proteins

  1. Mark L. Chiu

Published Online: 1 FEB 2012

DOI: 10.1002/0471140864.ps2901s67

Current Protocols in Protein Science

Current Protocols in Protein Science

How to Cite

Chiu, M. L. 2012. Introduction to Membrane Proteins. Current Protocols in Protein Science. 29:29.1:29.1.1–29.1.8.

Author Information

  1. Biologics Research, Biotechnology Center of Excellence, Janssen Research & Development, Radnor, Pennsylvania

Publication History

  1. Published Online: 1 FEB 2012
  2. Published Print: FEB 2012


Membrane proteins (MPs) mediate important physiological processes for the cell via extracellular and intracellular interactions. To better understand the biochemical and structural bases of these interactions, well-characterized preparations of purified MPs are required. This introduction reviews common problems encountered in MP preparation.


  • membrane protein;
  • purification and detergent solubilization;
  • protein stabilization