UNIT 1.7 Characterization of GABA Receptors

  1. S.J. Enna,
  2. Kenneth E. McCarson

Published Online: 2 DEC 2013

DOI: 10.1002/0471141755.ph0107s63

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Enna, S. and McCarson, K. E. 2013. Characterization of GABA Receptors. Current Protocols in Pharmacology. 63:1.7:1.7.1–1.7.20.

Author Information

  1. University of Kansas Medical Center, Kansas City, Kansas

Publication History

  1. Published Online: 2 DEC 2013


Described in this unit are ligand-binding assays for GABAA, GABAB, and the homomeric ρ GABAA (formerly GABAC) receptor recognition sites in brain tissue. Although GABA binding sites are present in peripheral organs, most research is directed toward examining these receptors in the CNS. These assays may also be used to determine the affinity of an unlabeled compound for the GABA binding sites. Excluded from the unit are ligand-binding assays for other components of the GABAA receptor complex, such as the benzodiazepine or ion-channel binding sites. Curr. Protoc. Pharmacol. 63:1.7.1-1.7.20. © 2013 by John Wiley & Sons, Inc.


  • gamma amino butyric acid;
  • neurotransmitter;
  • muscimol;
  • baclofen;
  • CNS;
  • ligand binding