Unit

UNIT 1.11 Characterization of Neuropeptide Y (NPY) Receptors

  1. William Karbon,
  2. Julie Marasco,
  3. Clarence Hale

Published Online: 1 MAY 2001

DOI: 10.1002/0471141755.ph0111s01

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Karbon, W., Marasco, J. and Hale, C. 2001. Characterization of Neuropeptide Y (NPY) Receptors. Current Protocols in Pharmacology. 1:1.11:1.11.1–1.11.11.

Author Information

  1. Amgen, Inc., Thousand Oaks, California

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: JUN 1998

Abstract

Neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP) constitute a trio of structurally related peptides that elicit a variety of physiological responses in targets including the brain, gut, and vascular smooth muscle. These actions are mediated by a family of G protein-coupled receptors, each of which exhibits a distinct pharmacological fingerprint. This unit describes protocols for identifying and characterizing the pharmacological properties of two NPY receptor subtypes, Y1 and Y2. At least four other members of this receptor family have been described (Y3, Y4, Y5 and y6), and a brief description of these receptors and relevant literature citations are also provided.