UNIT 1.11 Characterization of Neuropeptide Y (NPY) Receptors
Published Online: 1 MAY 2001
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Pharmacology
How to Cite
Karbon, W., Marasco, J. and Hale, C. 2001. Characterization of Neuropeptide Y (NPY) Receptors. Current Protocols in Pharmacology. 1:1.11:1.11.1–1.11.11.
- Published Online: 1 MAY 2001
- Published Print: JUN 1998
Neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP) constitute a trio of structurally related peptides that elicit a variety of physiological responses in targets including the brain, gut, and vascular smooth muscle. These actions are mediated by a family of G protein-coupled receptors, each of which exhibits a distinct pharmacological fingerprint. This unit describes protocols for identifying and characterizing the pharmacological properties of two NPY receptor subtypes, Y1 and Y2. At least four other members of this receptor family have been described (Y3, Y4, Y5 and y6), and a brief description of these receptors and relevant literature citations are also provided.