UNIT 1.19 Characterization of Histaminergic Receptors

  1. Marina Strakhova,
  2. Timothy A. Esbenshade

Published Online: 1 JUN 2007

DOI: 10.1002/0471141755.ph0119s37

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Strakhova, M. and Esbenshade, T. A. 2007. Characterization of Histaminergic Receptors. Current Protocols in Pharmacology. 37:1.19:1.19.1–1.19.24.

Author Information

  1. Abbott Laboratories, Abbott Park, Illinois

Publication History

  1. Published Online: 1 JUN 2007
  2. Published Print: JUN 2007


This unit describes radioligand binding protocols for histamine H1, H2, H3, and H4 receptors. Because these receptors demonstrate low amino acid sequence homology and divergent pharmacological characteristics, assay conditions vary for each. These protocols can be employed in high-throughput screening programs aimed at identifying selective agonists and antagonists for these sites.


  • histaminergic receptors;
  • H1 histamine receptors;
  • H2 histamine receptors;
  • H3 histamine receptors;
  • H4 histamine receptors;
  • radioligand binding assays;
  • antihistamines