Unit

UNIT 2.1 Overview of Signal Transduction

  1. Timothy A. Esbenshade1,
  2. Emir Duzic2

Published Online: 1 JAN 2006

DOI: 10.1002/0471141755.ph0201s31

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Esbenshade, T. A. and Duzic, E. 2006. Overview of Signal Transduction. Current Protocols in Pharmacology. 31:2.1:2.1.1–2.1.20.

Author Information

  1. 1

    Abbott Laboratories, Abbott Park, Illinois

  2. 2

    Cephalon Inc., West Chester, Pennsylvania

Publication History

  1. Published Online: 1 JAN 2006
  2. Published Print: DEC 2005

Abstract

Receptor- and ion channel-coupled signal transduction mechanisms are downstream communication processes used by regulatory molecules to modulate the essential cell processes of growth, differentiation and survival. Knowledge of signal transduction processes has dramatically increased in the past decade, and the basic principles of intracellular signaling are now quite well established. Cell signaling in higher organisms is a major, highly complex, phenomena that occupies a central position in current biomedical research. The complex machinery of intracellular signaling also has the potential to provide a wealth of novel drug discovery targets, from protein kinases, adaptor proteins, lipases, and cytoskeletal proteins, to nuclear effectors. This overview describes common features of cellular signaling pathways, including their interactions and responses to environmental stimuli. In particular, the overview focuses on the regulation of signaling pathways by protein functional-domain interactions as well as the intracellular proteins that mediate signal transduction.

Keywords:

  • Protein functional domains;
  • GPCR;
  • 7TM;
  • Heterotrimeric G protein;
  • Phospholipase;
  • Nucleotide Cyclase;
  • Tyrosine Kinase;
  • Serine/Threonine Kinase;
  • Phosphatase;
  • MAPK;
  • Ion Channel