UNIT 4.5 α-Adrenoceptor Assays
Published Online: 1 DEC 2012
Copyright © 2012 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Pharmacology
How to Cite
Abel, P. W. and Jain, N. 2012. α-Adrenoceptor Assays. Current Protocols in Pharmacology. 59:4.5:4.5.1–4.5.32.
- Published Online: 1 DEC 2012
α-Adrenoceptors mediate responses to activation of both peripheral sympathetic nerves and central noradrenergic neurons. They also serve as autoreceptors that modulate the release of norepinephrine (NE) and other neurotransmitters. There are two major classes of α-adrenoceptors, the α1- and α2. Each class is subdivided into three subtypes: α1A, α1B, α1D, and α2A, α2B, α2C. Described in this unit are in vitro isolated tissue methods used to study α-adrenoceptor functions and to identify novel ligands for these receptors. Detailed protocols describing use of isolated tissues to study the various α1- and α2-adrenoceptor subtypes are provided. Curr. Protoc. Pharmacol. 59:4.5.1-4.5.32. © 2012 by John Wiley & Sons, Inc.
- alpha adrenoceptors;
- isolated tissues