Unit

UNIT 4.17 Histamine Receptor Assays

  1. Nigel P. Shankley1,
  2. Magda F. Morton1,
  3. Gillian F. Watt2

Published Online: 1 NOV 2001

DOI: 10.1002/0471141755.ph0417s14

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Shankley, N. P., Morton, M. F. and Watt, G. F. 2001. Histamine Receptor Assays. Current Protocols in Pharmacology. 14:4.17:4.17.1–4.17.16.

Author Information

  1. 1

    R.W. Johnson Pharmaceutical Research Institute, La Jolla, California

  2. 2

    James Black Foundation Ltd., London, United Kingdom

Publication History

  1. Published Online: 1 NOV 2001
  2. Published Print: SEP 2001

Abstract

This unit describes three standard in vitro bioassays for studying histamine H1, H2 and H3 receptors in isolated intact tissues removed from the guinea pig. Both the H1 and H3 receptor assays are based on preparations of the ileum, whereas the spontaneously beating right atrium assay is used for the H2-receptor.

This unit describes three standard in vitro bioassays for studying histamine H1, H2 and H3 receptors in isolated intact tissue.