UNIT 5.1 Models of Cardiovascular Disease: Measurement of Arrhythmogenic/Antiarrhythmic Activity in the Guinea Pig
Published Online: 1 MAR 2009
Copyright © 2009 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Pharmacology
How to Cite
Guillaume, P., Provost, D. and Lacroix, P. 2009. Models of Cardiovascular Disease: Measurement of Arrhythmogenic/Antiarrhythmic Activity in the Guinea Pig. Current Protocols in Pharmacology. 44:5.1:5.1.1–5.1.5.
- Published Online: 1 MAR 2009
- Published Print: MAR 2009
The protocols described in this unit are used to assess the effects of new chemical entities on arrhythmias in the guinea pig. In the anesthetized guinea pig, arrhythmias are induced by a slow intravenous infusion of digoxin, which provokes extrasystoles, ventricular tachyarrhythmias, and ultimately cardiac arrest. Imipramine precipitates the occurrence of arrhythmias, whereas propranolol shows protection against them. Curr. Protoc. Pharmacol. 44:5.1.1-5.1.5. © 2009 by John Wiley & Sons, Inc.
- cardiovascular disease;