Unit

UNIT 5.1 Models of Cardiovascular Disease: Measurement of Arrhythmogenic/Antiarrhythmic Activity in the Guinea Pig

  1. Philippe Guillaume,
  2. Daniel Provost,
  3. Pierre Lacroix

Published Online: 1 MAR 2009

DOI: 10.1002/0471141755.ph0501s44

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Guillaume, P., Provost, D. and Lacroix, P. 2009. Models of Cardiovascular Disease: Measurement of Arrhythmogenic/Antiarrhythmic Activity in the Guinea Pig. Current Protocols in Pharmacology. 44:5.1:5.1.1–5.1.5.

Author Information

  1. Porsolt and Partners Pharmacology, Boulogne-Billancourt, France

Publication History

  1. Published Online: 1 MAR 2009
  2. Published Print: MAR 2009

Abstract

The protocols described in this unit are used to assess the effects of new chemical entities on arrhythmias in the guinea pig. In the anesthetized guinea pig, arrhythmias are induced by a slow intravenous infusion of digoxin, which provokes extrasystoles, ventricular tachyarrhythmias, and ultimately cardiac arrest. Imipramine precipitates the occurrence of arrhythmias, whereas propranolol shows protection against them. Curr. Protoc. Pharmacol. 44:5.1.1-5.1.5. © 2009 by John Wiley & Sons, Inc.

Keywords:

  • cardiovascular disease;
  • arrhythmias;
  • digoxin