Unit

UNIT 5.2 Models of Pulmonary Disease: Acute and Chronic Allergic Asthma in the Monkey and Acute and Chronic Viral Pulmonitis in the Mouse

  1. Craig D. Wegner,
  2. Thomas Shaughnessy,
  3. Donna Mussatto

Published Online: 1 MAY 2001

DOI: 10.1002/0471141755.ph0502s00

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Wegner, C. D., Shaughnessy, T. and Mussatto, D. 2001. Models of Pulmonary Disease: Acute and Chronic Allergic Asthma in the Monkey and Acute and Chronic Viral Pulmonitis in the Mouse. Current Protocols in Pharmacology. 00:5.2.1–5.2.19.

Author Information

  1. Abbott Laboratories, Abott Park, Illinois

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: MAR 1998

Abstract

Three models/protocols designed to mimic an inflammation process characteristic of a specific lung disease are described in this unit. Included are a single allergen inhalation in monkeys to model acute asthmatic episodes, repeated allergen inhalations in monkeys to model chronic asthma, and a lower-respiratory viral infection in mice to model acute and chronic viral alveolitis and bronchitis. In each case, alterations in lung functions believed to correlate with symptoms of the respective disease are measured along with pulmonary inflammation.