Unit

UNIT 5.3 Gastrointestinal Models: Intestinal Transit, Gastric Emptying, and Ulcerogenic Activity in the Rat

  1. Philippe Guillaume,
  2. Daniel Provost,
  3. Pierre Lacroix

Published Online: 1 SEP 2008

DOI: 10.1002/0471141755.ph0503s42

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Guillaume, P., Provost, D. and Lacroix, P. 2008. Gastrointestinal Models: Intestinal Transit, Gastric Emptying, and Ulcerogenic Activity in the Rat. Current Protocols in Pharmacology. 42:5.3:5.3.1–5.3.12.

Author Information

  1. Porsolt and Partners Pharmacology, Boulogne-Billancourt, France

Publication History

  1. Published Online: 1 SEP 2008
  2. Published Print: SEP 2008

Abstract

The protocols described in this unit are designed to assess the effects of substances on intestinal transit and gastric emptying and to evaluate their ulcerogenic potential on the stomach and duodenum of the rat. Examples of results obtained with atropine or morphine (intestinal transit), loperamide (gastric emptying), or indomethacin (ulcerogenic activity) used as reference substances are provided for illustrative purposes. Atropine and morphine clearly reduce intestinal transit. Atropine, morphine, and loperamide clearly reduce gastric emptying. Indomethacin shows a marked ulcerogenic potential. Curr. Protoc. Pharmacol. 42:5.3.1-5.3.12. © 2008 by John Wiley & Sons, Inc.

Keywords:

  • animal models of disease;
  • safety pharmacology;
  • gastrointestinal tract;
  • intestinal transit;
  • gastric emptying;
  • ulcerogenic activity