UNIT 5.9 Models of Affective Illness: Chronic Mild Stress

  1. Mariusz Papp

Published Online: 1 MAY 2001

DOI: 10.1002/0471141755.ph0509s01

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Papp, M. 2001. Models of Affective Illness: Chronic Mild Stress. Current Protocols in Pharmacology. 1:5.9:5.9.1–5.9.8.

Author Information

  1. Polish Academy of Sciences, Krakow, Poland

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: JUN 1998

This is not the most recent version of the article. View current version (1 JUN 2012)


Antidepressants can elevate the mood of depressed patients, but have no effect in normal (i.e., non-depressed) individuals. This characteristic makes predicting the clinical action of an antidepressant, based on the effects it has in normal laboratory animals, difficult. The best strategy for studying the psychobiological causes and treatment of depression involves the use of appropriate animal models. Of the few models that meet the criteria required for a valid animal model of depression, the chronic mild stress paradigm is the most valid and the most extensively investigated. In addition to the protocol describing generation of the model, data supporting the model's validation are presented along with a discussion of technical aspects of the procedure.