Unit

UNIT 5.11 Models of Urogenital Dysfunction: Urinary Urge Incontinence (UUI) in Anesthetized Dog and Rat Models

  1. Donald Newgreen1,
  2. Charles Anderson1,
  3. Philip Nunn1,
  4. Anthony Carter1,
  5. Mark Bushfield2

Published Online: 1 MAY 2001

DOI: 10.1002/0471141755.ph0511s02

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Newgreen, D., Anderson, C., Nunn, P., Carter, A. and Bushfield, M. 2001. Models of Urogenital Dysfunction: Urinary Urge Incontinence (UUI) in Anesthetized Dog and Rat Models. Current Protocols in Pharmacology. 2:5.11:5.11.1–5.11.15.

Author Information

  1. 1

    Discovery Biology, Pfizer Central Research, Kent, United Kingdom

  2. 2

    Cambridge Drug Discovery, Cambridge, United Kingdom

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: SEP 1998

Abstract

This unit describes a model system for the measurement of the effects of compounds on bladder function in anesthetized dog and rat. A protocol is also described for measuring nerve-stimulated salivary secretion which is particularly relevant when investigating agents that modulate parasympathetic drive (such as muscarinic antagonists), since it allows for the measurement of relative selectivity of bladder function over salivation. This unit describes a model system for the measurement of the effects of compounds on bladder function in anesthetized dog and