UNIT 5.12 Models of Urogenital Dysfunction: Assessment of Volume-Evoked Micturition Reflex (VEMR) in the Conscious Rat by Cystometry
Published Online: 1 MAY 2001
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Pharmacology
How to Cite
Nunn, P., Williamson, I., Newgreen, D. and Bushfield, M. 2001. Models of Urogenital Dysfunction: Assessment of Volume-Evoked Micturition Reflex (VEMR) in the Conscious Rat by Cystometry. Current Protocols in Pharmacology. 2:5.12:5.12.1–5.12.9.
- Published Online: 1 MAY 2001
- Published Print: SEP 1998
This unit describes a conscious rat model that allows the investigation of compounds administered by various routes (e.g., oral, intravenous and subcutaneous). This procedure can be used to examine the effects of agents on supraspinal, spinal and peripheral control of the micturition reflex, in addition to effects on parasympathetic neurotransmission and detrusor relaxation. One advantage to this procedure over anesthetized dog and rat models is the ability to determine pharmacological effects in the absence of possible interfering effects of anesthetics.