Unit

UNIT 5.12 Models of Urogenital Dysfunction: Assessment of Volume-Evoked Micturition Reflex (VEMR) in the Conscious Rat by Cystometry

  1. Philip Nunn1,
  2. Ian Williamson1,
  3. Donald Newgreen1,
  4. Mark Bushfield2

Published Online: 1 MAY 2001

DOI: 10.1002/0471141755.ph0512s02

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Nunn, P., Williamson, I., Newgreen, D. and Bushfield, M. 2001. Models of Urogenital Dysfunction: Assessment of Volume-Evoked Micturition Reflex (VEMR) in the Conscious Rat by Cystometry. Current Protocols in Pharmacology. 2:5.12:5.12.1–5.12.9.

Author Information

  1. 1

    Discovery Biology, Pfizer Central Research, Sandwich Kent, United Kingdom

  2. 2

    Cambridge Drug Discovery, Cambridge, United Kingdom

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: SEP 1998

Abstract

This unit describes a conscious rat model that allows the investigation of compounds administered by various routes (e.g., oral, intravenous and subcutaneous). This procedure can be used to examine the effects of agents on supraspinal, spinal and peripheral control of the micturition reflex, in addition to effects on parasympathetic neurotransmission and detrusor relaxation. One advantage to this procedure over anesthetized dog and rat models is the ability to determine pharmacological effects in the absence of possible interfering effects of anesthetics.