Unit

UNIT 5.14 Models of Neurological Disease (Alzheimer's Disease): Spatial Discrimination Water Maze Test in Septal-Lesioned Rats

  1. Michael W. Decker

Published Online: 1 AUG 2001

DOI: 10.1002/0471141755.ph0514s03

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Decker, M. W. 2001. Models of Neurological Disease (Alzheimer's Disease): Spatial Discrimination Water Maze Test in Septal-Lesioned Rats. Current Protocols in Pharmacology. 3:5.14:5.14.1–5.14.10.

Author Information

  1. Abbott Laboratories, Abbott Park, Illinois

Publication History

  1. Published Online: 1 AUG 2001
  2. Published Print: DEC 1998

Abstract

Models of Alzheimer s disease currently focus on symptomatology, as understanding of the etiology of the disorder is not yet sufficiently advanced to model the disease process in animals. Moreover, currently available treatments are purely palliative in nature. Given that cognitive dysfunction is a central feature of the disease, animal models of cognitive dysfunction are frequently used to evaluate the therapeutic potential of test compounds. This unit presents a rat model in which a brain lesion is produced which disrupts septohippocampal function, thus impairing performance on a spatial learning task (the Morris water maze).