Unit

UNIT 5.15 Models of Schizophrenia: Phencyclidine Disruption of Prepulse Inhibition (PPI) of Startle in Rats

  1. John H. Kehne,
  2. Diane C. Hoffman,
  3. James V. Cassella

Published Online: 1 MAY 2001

DOI: 10.1002/0471141755.ph0515s03

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Kehne, J. H., Hoffman, D. C. and Cassella, J. V. 2001. Models of Schizophrenia: Phencyclidine Disruption of Prepulse Inhibition (PPI) of Startle in Rats. Current Protocols in Pharmacology. 3:5.15:5.15.1–5.15.12.

Author Information

  1. Neurogen Corporation, Branford, Connecticut

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: DEC 1998

Abstract

Modern theories of schizophrenia implicate deficits in glutamatergic transmission in the etiology of this disorder. This unit describes an animal model in which a deficit in glutamatergic transmission is induced pharmacologically by the NMDA receptor ion channel blocker phencyclidine. Reversal of the resulting behavioral impairment, the reduction of sensory-motor gating as measured by prepulse inhibition, can be used as a method for evaluating novel treatments for schizophrenia.