UNIT 5.15 Models of Schizophrenia: Phencyclidine Disruption of Prepulse Inhibition (PPI) of Startle in Rats
Published Online: 1 MAY 2001
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Pharmacology
How to Cite
Kehne, J. H., Hoffman, D. C. and Cassella, J. V. 2001. Models of Schizophrenia: Phencyclidine Disruption of Prepulse Inhibition (PPI) of Startle in Rats. Current Protocols in Pharmacology. 3:5.15:5.15.1–5.15.12.
- Published Online: 1 MAY 2001
- Published Print: DEC 1998
Modern theories of schizophrenia implicate deficits in glutamatergic transmission in the etiology of this disorder. This unit describes an animal model in which a deficit in glutamatergic transmission is induced pharmacologically by the NMDA receptor ion channel blocker phencyclidine. Reversal of the resulting behavioral impairment, the reduction of sensory-motor gating as measured by prepulse inhibition, can be used as a method for evaluating novel treatments for schizophrenia.