Unit

UNIT 5.17 Models for Assessing Antipsychotics: Antagonism of Amphetamine-Induced Hyperactivity and Stereotypies in Mice

  1. Sylvain Roux,
  2. Anne-Marie Hay,
  3. Ruger D. Porsolt

Published Online: 1 MAY 2001

DOI: 10.1002/0471141755.ph0517s04

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Roux, S., Hay, A.-M. and Porsolt, R. D. 2001. Models for Assessing Antipsychotics: Antagonism of Amphetamine-Induced Hyperactivity and Stereotypies in Mice. Current Protocols in Pharmacology. 4:5.17:5.17.1–5.17.7.

Author Information

  1. Phoenix International Pharmacology, Le Kremlin-Bicêtre Cedex, France

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: MAR 1999

Abstract

All classical antipsychotics, such as chlorpromazine and haloperidol, have potent dopamine receptor-blocking properties

This unit describes the rat anti-Thy-1.1 model of acute proliferative glomerulonephritis for the study of chronic renal insufficiency. A procedure is detailed for the induction of glomerulonephritis in rats as well as measurement of daily urinary excretion of protein, which is a convenient, primary screening tool. The unit also provides methods for assessment of glomerular filtration rate and effective renal plasma flow in anesthetized rats with anti-Thy-1.1-induced renal insufficiency.