UNIT 5.17 Models for Assessing Antipsychotics: Antagonism of Amphetamine-Induced Hyperactivity and Stereotypies in Mice
Published Online: 1 MAY 2001
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Pharmacology
How to Cite
Roux, S., Hay, A.-M. and Porsolt, R. D. 2001. Models for Assessing Antipsychotics: Antagonism of Amphetamine-Induced Hyperactivity and Stereotypies in Mice. Current Protocols in Pharmacology. 4:5.17:5.17.1–5.17.7.
- Published Online: 1 MAY 2001
- Published Print: MAR 1999
All classical antipsychotics, such as chlorpromazine and haloperidol, have potent dopamine receptor-blocking properties
This unit describes the rat anti-Thy-1.1 model of acute proliferative glomerulonephritis for the study of chronic renal insufficiency. A procedure is detailed for the induction of glomerulonephritis in rats as well as measurement of daily urinary excretion of protein, which is a convenient, primary screening tool. The unit also provides methods for assessment of glomerular filtration rate and effective renal plasma flow in anesthetized rats with anti-Thy-1.1-induced renal insufficiency.