UNIT 5.19 Models for Environmentally Induced Eating Disorders: Dietary Hyperphagia and Anorexia Nervosa
Published Online: 1 MAY 2001
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Pharmacology
How to Cite
Pelleymounter, M. A., Kant, R. and Aravich, P. 2001. Models for Environmentally Induced Eating Disorders: Dietary Hyperphagia and Anorexia Nervosa. Current Protocols in Pharmacology. 5:5.19:5.19.1–5.19.15.
- Published Online: 1 MAY 2001
- Published Print: JUN 1999
The two protocols in this unit provide suggestions for constructing models of eating disorders that are at the opposite ends of the spectrum: dietary hyperphagia and anorexia nervosa. The greatest degree of dietary hyperphagia is induced by giving rats or mice access to a daily choice of highly palatable foods (e.g., chocolate or bread) in addition to their regular chow. Like humans, rats overeat and actually develop physiological requirements for these foods. This model can be used to test the effects of putative anorectic agents on both acute and chronic administration regimens. The second protocol describes a model of compulsive behavior that results in profound weight loss, which is produced by moderate food deprivation along with continuous access to exercise wheels.