UNIT 5.20 Overview of the Use of Transgenic Animals in CNS Drug Discovery
Published Online: 1 MAY 2001
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Pharmacology
How to Cite
Nestler, E. J. and Olivier, B. 2001. Overview of the Use of Transgenic Animals in CNS Drug Discovery. Current Protocols in Pharmacology. 7:5.20:5.20.1–5.20.8.
- Published Online: 1 MAY 2001
- Published Print: DEC 1999
This overview highlights how transgenic mice, and related genetic manipulations, can contribute in important ways to the goal of developing novel treatments for neuropsychiatric disorders. A brief background of the field of drug discovery is covered and then new animal models of CNS disorders are discussed along with the topics of target validation, identification of novel targets, and functional genomics.