UNIT 5.20 Overview of the Use of Transgenic Animals in CNS Drug Discovery

  1. Eric J. Nestler1,2,
  2. Berend Olivier1,2

Published Online: 1 MAY 2001

DOI: 10.1002/0471141755.ph0520s07

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Nestler, E. J. and Olivier, B. 2001. Overview of the Use of Transgenic Animals in CNS Drug Discovery. Current Protocols in Pharmacology. 7:5.20:5.20.1–5.20.8.

Author Information

  1. 1

    Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut

  2. 2

    PsychoGenics, Inc., Tarrytown, New York

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: DEC 1999


This overview highlights how transgenic mice, and related genetic manipulations, can contribute in important ways to the goal of developing novel treatments for neuropsychiatric disorders. A brief background of the field of drug discovery is covered and then new animal models of CNS disorders are discussed along with the topics of target validation, identification of novel targets, and functional genomics.