Unit

UNIT 5.21 Models of Renal Insufficiency: The Anti-Thy-1.1 Model of Acute Proliferative Glomerulonephritis

  1. Glenn A. Reinhart,
  2. Bryan F. Cox

Published Online: 1 MAY 2001

DOI: 10.1002/0471141755.ph0521s07

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Reinhart, G. A. and Cox, B. F. 2001. Models of Renal Insufficiency: The Anti-Thy-1.1 Model of Acute Proliferative Glomerulonephritis. Current Protocols in Pharmacology. 7:5.21:5.21.1–5.21.13.

Author Information

  1. Abbott Laboratories, Abbott Park, Illinois

Publication History

  1. Published Online: 1 MAY 2001
  2. Published Print: DEC 1999

Abstract

This unit describes the rat anti-Thy-1.1 model of acute proliferative glomerulonephritis for the study of chronic renal insufficiency. A procedure is detailed for the induction of glomerulonephritis in rats as well as measurement of daily urinary excretion of protein, which is a convenient, primary screening tool. The unit also provides methods for assessment of glomerular filtration rate and effective renal plasma flow in anesthetized rats with anti-Thy-1.1-induced renal insufficiency.