Unit

UNIT 5.24 Classic In Vivo Cancer Models: Three Examples of Mouse Models Used in Experimental Therapeutics

  1. Anna Kruczynski,
  2. Bridget T. Hill

Published Online: 1 FEB 2002

DOI: 10.1002/0471141755.ph0524s15

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Kruczynski, A. and Hill, B. T. 2002. Classic In Vivo Cancer Models: Three Examples of Mouse Models Used in Experimental Therapeutics. Current Protocols in Pharmacology. 15:5.24.1–5.24.16.

Author Information

  1. Centre de Recherche Pierre Fabre, Cedex, France

Publication History

  1. Published Online: 1 FEB 2002
  2. Published Print: DEC 2001

Abstract

Transplantable animal tumors have been associated with the discovery of most clinically active anticancer agents. They are still useful today in conducting detailed evaluations of new candidate anticancer drugs. Three protocols relating to transplantable experimental tumors are described in this unit. Included are the intravenously-implanted murine P388 leukemia, the subcutaneously-implanted murine B16 melanoma and two examples of subcutaneously-implanted human tumor xenografts, the LX-1 (lung) and MX-1 (breast) tumors.