UNIT 5.25 Overview of Animal Models of Asthma

  1. Brendan J. Canning

Published Online: 1 MAY 2002

DOI: 10.1002/0471141755.ph0525s16

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Canning, B. J. 2002. Overview of Animal Models of Asthma. Current Protocols in Pharmacology. 16:5.25:5.25.1–5.25.15.

Author Information

  1. Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland

Publication History

  1. Published Online: 1 MAY 2002
  2. Published Print: MAR 2002


Asthma is an inflammatory disease characterized by airways obstruction, airways hyperresponsiveness, excessive mucous secretion and cough. Guinea pig airways display many anatomical, physiological and pharmacological attributes of human airways, making this species ideal for modeling the asthmatic condition. This unit provides an overview of animal models of asthma, including definitions, descriptions of available animal models, and discussion of numerous critical issues to consider before designing a model to study this complex disease.