UNIT 5.27 Models of Cardiac Ischemia-Reperfusion Injury in Dogs and Rats
Published Online: 1 MAY 2002
Copyright © 2003 by John Wiley and Sons, Inc.
Lab Protocol Title
Current Protocols in Pharmacology
How to Cite
Gross, G. J. 2002. Models of Cardiac Ischemia-Reperfusion Injury in Dogs and Rats. Current Protocols in Pharmacology. 16:5.27.1–5.27.17.
- Published Online: 1 MAY 2002
- Published Print: MAR 2002
A marked reduction in coronary blood flow produces a reduction in myocardial function, electrocardiographic abnormalities and eventually a myocardial infarction if the ischemic episode were to persist for more than 20 to 30 min. There have been numerous studies in animal models in search of a magic bullet or drug that can ameliorate these symptoms and result in a reduction in infarct size, improvement in the recovery of contractile function, and abrogation of malignant ventricular arrhythmias in humans. This unit describes two animal models of myocardial ischemia/reperfusion injury which are used to evaluate pharmacological agents that may eventually demonstrate cardioprotective activity in a clinical setting.