UNIT 5.27 Models of Cardiac Ischemia-Reperfusion Injury in Dogs and Rats

  1. Garrett J. Gross

Published Online: 1 MAY 2002

DOI: 10.1002/0471141755.ph0527s16

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Gross, G. J. 2002. Models of Cardiac Ischemia-Reperfusion Injury in Dogs and Rats. Current Protocols in Pharmacology. 16:5.27:5.27.1–5.27.17.

Author Information

  1. Medical College of Wisconsin, Milwaukee, Wisconsin

Publication History

  1. Published Online: 1 MAY 2002
  2. Published Print: MAR 2002


A marked reduction in coronary blood flow produces a reduction in myocardial function, electrocardiographic abnormalities and eventually a myocardial infarction if the ischemic episode were to persist for more than 20 to 30 min. There have been numerous studies in animal models in search of a magic bullet or drug that can ameliorate these symptoms and result in a reduction in infarct size, improvement in the recovery of contractile function, and abrogation of malignant ventricular arrhythmias in humans. This unit describes two animal models of myocardial ischemia/reperfusion injury which are used to evaluate pharmacological agents that may eventually demonstrate cardioprotective activity in a clinical setting.