Unit

UNIT 5.33 Electrical Amygdala Kindling

  1. N. Dürmüller,
  2. R.D. Porsolt

Published Online: 1 NOV 2003

DOI: 10.1002/0471141755.ph0533s22

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Dürmüller, N. and Porsolt, R. 2003. Electrical Amygdala Kindling. Current Protocols in Pharmacology. 22:5.33:5.33.1–5.33.17.

Author Information

  1. Porsolt and Partners Pharmacology, Boulogne Billancourts, France

Publication History

  1. Published Online: 1 NOV 2003
  2. Published Print: SEP 2003

Abstract

This unit describes a method of electrical amygdala kindling in the rat. This procedure requires mastery of stereotaxic electrode implantation which is not covered in the current unit. Also, the investigator must have a sound knowledge of electronics and computing. The text gives instructions on how to render rats epileptic, how to determine the effects of compounds in kindled rats, and how to analyze the data. Results with three reference substances are illustrated. These substances are used in the clinic and give robust results in kindling.

Keywords:

  • chronically implanted rats;
  • electrical stimulation;
  • complex partial seizures;
  • kindling