UNIT 5.42 MPTP-Induced Models of Parkinson's Disease in Mice and Non-Human Primates

  1. Naomi P. Visanji1,
  2. Jonathan M. Brotchie2

Published Online: 1 JUL 2005

DOI: 10.1002/0471141755.ph0542s29

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Visanji, N. P. and Brotchie, J. M. 2005. MPTP-Induced Models of Parkinson's Disease in Mice and Non-Human Primates. Current Protocols in Pharmacology. 29:5.42:5.42.1–5.42.13.

Author Information

  1. 1

    Toronto Western Research Institute, Toronto, Ontario, Canada

  2. 2

    Toronto Western Research Institute and Atuka Ltd., Toronto, Ontario, Canada

Publication History

  1. Published Online: 1 JUL 2005
  2. Published Print: JUN 2005


The pro-toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is widely used to create animal models of Parkinson's disease. This unit describes protocols for the production of stable and substantial lesions in the dopaminergic nigrostriatal pathway of mice and non-human primates. The models can be employed for assessing the neural mechanisms underlying the development of Parkinson's disease and for screening potential therapies for the treatment of this condition.


  • MPTP;
  • Parkinson's disease;
  • primate;
  • mouse;
  • levodopa-induced dyskinesia