Unit

UNIT 5.43 Dog EEG for Wake-Promotion Studies

  1. Régis Parmentier,
  2. Denis Bricout,
  3. Emmanuel Brousseau,
  4. Thierry Giboulot

Published Online: 1 OCT 2006

DOI: 10.1002/0471141755.ph0543s34

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Parmentier, R., Bricout, D., Brousseau, E. and Giboulot, T. 2006. Dog EEG for Wake-Promotion Studies. Current Protocols in Pharmacology. 34:5.43:5.43.1–5.43.12.

Author Information

  1. Centre de Développement Cephalon France, Maisons Alfort, France

Publication History

  1. Published Online: 1 OCT 2006
  2. Published Print: SEP 2006

Abstract

Described in this unit is a protocol for investigating the wake-promoting activity of new chemical entities (NCEs) in dog. The experimental approach is based on scoring of sleep/wake stages in animals implanted with a telemetry device for recording EMG and cortical EEG signals. A major advantage of this procedure is that it is conducted in nontethered animals, limiting possible bias and complications encountered with conventional recording systems. In this procedure, polygraphic recording is conducted using four implanted beagles. Results of studies with modafinil, a wake-promoting agent, are described to demonstrate the utility of this test procedure.

Keywords:

  • sleep-wake cycle;
  • dog;
  • EEG;
  • wake promoting activity;
  • animal models