UNIT 5.51 Animal Models of Collagen-Induced Arthritis

  1. Stéphanie Wagner,
  2. Julien Bindler,
  3. Emile Andriambeloson

Published Online: 1 DEC 2008

DOI: 10.1002/0471141755.ph0551s43

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Wagner, S., Bindler, J. and Andriambeloson, E. 2008. Animal Models of Collagen-Induced Arthritis. Current Protocols in Pharmacology. 43:5.51:5.51.1–5.51.8.

Author Information

  1. Neurofit SAS, Illkirch, France

Publication History

  1. Published Online: 1 DEC 2008
  2. Published Print: DEC 2008


Collagen-induced arthritis in rats is associated with inflammatory polyarthritis, sharing clinical and pathological features with those of human rheumatoid arthritis (RA). Described in this unit is a protocol for consistently inducing arthritis in female Lewis rats by immunizing them with bovine type II collagen (CII) emulsified in complete Freund's adjuvant. This model is of value not only in defining the underlying pathogenesis of RA, but also as a tool for evaluating pharmacological strategies for treating this condition. Curr. Protoc. Pharmacol. 43:5.51.1-5.51.8. © 2008 by John Wiley & Sons, Inc.


  • rheumatoid arthritis;
  • collagen;
  • animal model;
  • inflammation;
  • rat