Unit

UNIT 5.55 Chemically Induced Mouse Models of Colitis

  1. Maximilian J. Waldner1,2,
  2. Markus F. Neurath1,2

Published Online: 1 SEP 2009

DOI: 10.1002/0471141755.ph0555s46

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Waldner, M. J. and Neurath, M. F. 2009. Chemically Induced Mouse Models of Colitis. Current Protocols in Pharmacology. 46:5.55:5.55.1–5.55.15.

Author Information

  1. 1

    Institute of Molecular Medicine, University of Mainz, Mainz, Germany

  2. 2

    Department of Medicine, University of Erlangen, Erlangen, Germany

Publication History

  1. Published Online: 1 SEP 2009
  2. Published Print: SEP 2009

Abstract

Crohn's disease (CD) and ulcerative colitis (UC), both of which are referred to as inflammatory bowel disease (IBD), are chronic inflammatory disorders of the gastrointestinal tract that have characteristic clinical, pathological, endoscopic, and radiologic features. Knowledge about the pathogenesis of IBD has dramatically increased in recent years based in part on the use of experimental models of IBD. Although none of these models exactly mimics the human disorder, they have proven to be useful for studying many important aspects of these conditions. Detailed in this unit is a description of the most commonly used chemically induced mouse models of IBD. These include trinitrobenzene sulfonic acid (TNBS), oxazolone, and acute or chronic dextran sodium sulfate (DSS) colitis models. Curr. Protoc. Pharmacol. 46:5.55.1-5.55.15. © 2009 by John Wiley & Sons, Inc.

Keywords:

  • inflammatory bowel disease;
  • colitis;
  • disease models;
  • animal;
  • mice;
  • dextran sulfate;
  • trinitrobenzenesulfonic acid