UNIT 5.61 Overview of Animal Models of Obesity
Published Online: 1 SEP 2012
Copyright © 2012 by John Wiley & Sons, Inc.
Lab Protocol Title
Current Protocols in Pharmacology
How to Cite
Lutz, T. A. and Woods, S. C. 2012. Overview of Animal Models of Obesity. Current Protocols in Pharmacology. 58:5.61:5.61.1–5.61.18.
- Published Online: 1 SEP 2012
The focus of this overview is on the animal models of obesity most commonly utilized in research. The models include monogenic models in the leptin pathway, polygenic diet-dependent models, and, in particular for their historical perspective, surgical and chemical models of obesity. However, there are far too many models to consider all of them comprehensively, especially those caused by selective molecular genetic approaches modifying one or more genes in specific populations of cells. Further, the generation and use of inducible transgenic animals (induced knock-out or knock-in) is not covered, even though they often carry significant advantages compared to traditional transgenic animals, e.g., influences of the genetic modification during the development of the animals can be minimized. The number of these animal models is simply too large to be covered in this unit. Curr. Protoc. Pharmacol. 58:5.61.1-5.61.18. © 2012 by John Wiley & Sons, Inc.
- monogenic models;
- polygenic models;
- genetic engineering;
- surgical model;