UNIT 6.10 Overview of Pharmacogenetics

  1. David A. Katz

Published Online: 1 MAR 2007

DOI: 10.1002/0471141755.ph0610s36

Current Protocols in Pharmacology

Current Protocols in Pharmacology

How to Cite

Katz, D. A. 2007. Overview of Pharmacogenetics. Current Protocols in Pharmacology. 36:6.10:6.10.1–6.10.24.

Author Information

  1. Abbott Laboratories, Abbott Park, Illinois

Publication History

  1. Published Online: 1 MAR 2007
  2. Published Print: MAR 2007


Pharmacogenetics is the study of relationships between genetic variation and inter-individual differences with respect to drug response. As the field has matured over the past 15 years, a remarkable diversity of pathways, variation types, and mechanisms have been found to be relevant pharmacogenetic factors. Today, pharmacogenetics is becoming more important in pharmacology for target validation, lead optimization, and understanding of idiosyncratic toxicity. This unit provides an overview of the history of pharmacogenetics and current research applications in drug discovery, as well as a discussion of research quality issues relevant to human subjects research in the pharmacogenetics laboratory.


  • pharmacogenetics;
  • genotype-phenotype correlations;
  • drug discovery;
  • toxicogenomics;
  • drug development